3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium

Name	Alstonine
Synonyms	Alstonine Aids002662 Aids-002662 3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)-
CAS	642-18-2

Molecular Formula	C21H20N2O3
Molar Mass	348.4
Appearance	Yellow powder
Storage Condition	2-8℃
In vitro study	Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.
In vivo study	In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg. Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages. Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.

biological activity

alstonin is a major indole alkaloid compound of botanical drugs. Alstonin has antipsychotic, anti-Anxiety, anticancer and antimalarial properties.

Last Update：2024-04-09 15:16:54

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CAS: 642-18-2
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium Request for Quotation